ABSTRACT
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report that a long noncoding RNA, named autophagy promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. The results show that miR-188-3p suppresses autophagy and myocardial infarction by targeting ATG7. Further, we find that APF lncRNA regulates miR-188-3p, and thus affects ATG7 expression, autophagic cell death and myocardial infarction. Our present study reveals a novel regulating model of autophagic programme, which comprises APF, miR-188-3p and ATG7 in the heart. Modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of myocardial infarction and heart failure.
Subject(s)
Autophagy/genetics , Heart Failure/genetics , MicroRNAs/genetics , Microtubule-Associated Proteins/genetics , Myocardial Infarction/genetics , RNA, Long Noncoding/genetics , Animals , Apoptosis/genetics , Autophagy-Related Protein 7 , Base Sequence , Gene Expression Regulation , Heart Failure/metabolism , Heart Failure/pathology , Male , Mice , Mice, Inbred C57BL , MicroRNAs/metabolism , Microtubule-Associated Proteins/metabolism , Molecular Sequence Data , Myocardial Infarction/metabolism , Myocardial Infarction/pathology , Myocytes, Cardiac/metabolism , Myocytes, Cardiac/pathology , Oligonucleotides/genetics , Oligonucleotides/metabolism , Primary Cell Culture , RNA, Long Noncoding/antagonists & inhibitors , RNA, Long Noncoding/metabolism , Signal TransductionABSTRACT
OBJECTIVE: To study the characteristics of articles, citations and authors in Chinese Journal of Burns (Chin J Burns). METHODS: The date concerning articles, citations and authors of Chin J Burns from 2003 to 2005 were collected and analyzed in terms of bibliographic parameters. RESULTS: There were 741 papers published in Chin J Burns during these 3 years, and papers with funded projects accounted for 19.7%. The average number of articles per issue was 41,with paper density of 0.59, and publication date were 15 months in average after submission. Among these papers, 87.9% of which were shared with co-authors, with a corporation rate of 3.94. The papers with citation accounted for 78.7%, and 90.6% of all the citations came from journals, especially English journals. The Price's indicator was 65.6%. CONCLUSION: Chinese Journal of Burns, an academic journal of high quality, with strong influence, pushes the discipline of Burns medicine in China forward.
